discoid lupus erythematosus

Aus allen Formen des kutanen Lupus erythematodes (CLE) kann sich ein systemischer Lupus erythematodes (SLE) entwickeln. [3] If the patients does indeed have discoid lupus, the doctor may see tiny spines of keratin that look like carpet tacks and are called langue au chat. [3][5], In order to help with diagnosis, the doctor may peel off the top layer of scale from a patient's lesions in order to look at its underside. Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. Dust Mites: Minimizing Exposure in Dogs and Cats. ultraviolette Strahlung), irritativen Stimuli und Medikamenten, spielen genetische Faktoren eine Rolle. [3][5] In addition to lesions in the typical above-the-neck locations, patients with generalized discoid lupus often have lesions on the thorax and the arms. Liegt der Herd im Bereich der behaarten Kopfhaut, entwickelt sich darüber hinaus eine bleibende Alopezie. Frauen sollen nach manchen Quellen etwa 3x häufiger betroffen sein als Männer, nach anderen Quellen etwa gleich häufig. Bitte logge Dich ein, um diesen Artikel zu bearbeiten. There are several types of cutaneous lupus. However, it can also present as a diffuse morbilliform eruption with erythema and edem… [3] These patients are often bald, with abnormal skin pigment on their scalp, and have severe scarring of the face and arms. [3] The lesions often lose skin pigment and become white with areas of increased skin pigment, with or without areas of redness, and have a sunken appearance. Elman SA, Joyce C, Nyberg F, Furukawa F, Goodfield M, Hasegawa M, et al. [3][5], Discoid lupus has an unknown incidence, although it is two to three times more common than systemic lupus erythematosus. Discoid lupus erythematosus (DLE) is a rare disorder in childhood, with 22 cases reported in the English-language literature. [3], When patients develop discoid lupus in childhood, it differs from typical discoid lupus in several ways. 2020 Jan. 45 (1):89 … Im Stratum basale kommt es zu einer Degeneration der Stammzellen mit zahlreichen Einzelzellnekrosen, die sich als eosinophile Zellreste darstellen. Correlation of clinical features with laboratory findings in lupus erythematosus. [3], Rarely, patients may have lesions above and below the neck; these patients have generalized discoid lupus erythematosus. [3], In general, patients with discoid lupus who have only skin disease and no systemic symptoms have a genetically distinct disease from patients with SLE. These l… Arch Dermatol. These patients rarely present with significant organ involvement and generally have a good prognosis (3,4). [3] These patients also typically do not have any abnormal sensitivity to the sun. Im oberen Korium sieht man als Zeichen der Immunreaktion ein perivasales Infiltrat aus Lymphozyten sowie einen Abbau der Kollagenfasern und elastischen Fasern. [3] Patients with generalized discoid lupus often have abnormal lab tests, such as an elevated ESR or a low white blood cell count. [4], Finally, many patients with systemic lupus also develop discoid lupus lesions. [3] They also often have auto-antibodies, such as ANA or anti-ssDNA antibody. 1975 Nov. 111(11):1448-52. . discoid lupus erythematosus (DLE) a superficial inflammation of the skin, marked by red macules up to 3 to 4 cm in width, and covered with scanty adherent scales, which extend into spreading follicles that fall off and leave scars. Lupus erythematodes. [4], Treatment for discoid lupus erythematosus includes smoking cessation and a sunscreen that protects against both UVA and UVB light as well as very strong topical steroids or steroids injected into the lesions. Prevalence of pruritus in cutaneous lupus erythematosus: brief report of … Acute cutaneous lupus erythematosus (ACLE) most commonly presents as symmetric erythema overlying the malar cheeks and nasal bridge with sparing of the nasolabial folds (butterfly rash). [5] The doctor will order tests to check for anti-nuclear antibodies in the patient's serum, low white blood cell levels, and protein and/or blood in the urine. Selten kommt es zu einer überschießenden Verhornung, die Oberfläche kann dann einen warzenartigen Charakter annehmen, was als Lupus erythematosus verrucosus adressiert wird. [3] They can have a smooth surface or have visible, dilated hair follicles on the surface. [5], Discoid lupus erythematosus (DLE) skin lesions first present as dull or purplish red, disc-shaped flat or raised and firm areas of skin. [3] On lighter skin, the lesions often develop a gray color or have very little color change. [3] Discoid lupus can be divided into localized, generalized, and childhood discoid lupus. [3] Patients who develop discoid lupus in childhood also have their own sub-type of disease. Es gibt aber auch Verlaufsformen, bei denen noch andere Organe mitbeteiligt sind. Der diskoide Lupus erythematodes, kurz DLE, ist ein Subtyp des kutanen Lupus erythematodes (CLE). [11], Singer Michael Jackson was reportedly diagnosed with discoid lupus in 1984; the condition might have damaged his nasal cartilage and led to some of his cosmetic surgery. DLE is different from systemic lupus erythematosus (SLE), the most common form of lupus, which can affect any part of the body. Discoid lupus erythematosus (DLE) is responsible for 50-85% of cases of CLE and occurs 2-3 times more frequently in women than in men. [5] However, scientists do not understand the connection between these antibodies and the lesions seen in discoid lupus. [4] These patients have firm, nontender nodules with defined borders underneath their discoid lupus lesions. The center areas may appear lighter in color with a rim darker than the normal skin. Klicke hier, um einen neuen Artikel im DocCheck Flexikon anzulegen. Dezember 2018 um 14:40 Uhr bearbeitet. [5], Most experts consider DLE an autoimmune disease since pathologists see antibodies when they biopsy the lesions and look at the tissue under the microscope. Clin Exp Dermatol. In der Hautbiopsie zeigt sich unter direkter Immunfluoreszenz das typische Lupusband, eine Anreicherung von IgA, IgG, IgM sowie Komplementfaktor C1 und C3 an der Grenze zwischen Dermis und Epidermis. These lesion… Hypertrophic lupus erythematosus (HLE) may be more common as a variant of discoid lupus erythematosus (DLE) than is reported in the literature. Distemper in Dogs. [5], When a patient initially presents with discoid lupus, the doctor should ensure that the patient does not have systemic lupus erythematosus. discoid lupus erythematosus causes. dermis.net:80. dermis.net:80. Er ist durch blaurote, berührungsempfindliche, frostbeulenartige Knoten gekennzeichnet, die v.a. This condition causes a … Discoid Lupus Erythematosus Definition Discoid lupus erythematosus (DLE) is a disease in which coin-shaped (discoid) red bumps appear on the skin. [3], Diagnosis is confirmed through biopsy. Diese Seite wurde zuletzt am 14. Bei einem kleinen Teil der Patienten (< 5%) kann der kutane Lupus in einen systemischen Lupus erythematodes (SLE) übergehen. Discoid lupus is the most common type of CLE. Es können auch andere Körperregionen betroffen sein, wie das Dekolleté oder die Streckseiten der Extremitäten. [2][7] If this does not help the patient, his or her physician can prescribe an antimalarial medication such as oral hydroxychloroquine or chloroquine. Diskospondylitis (Intervertebral Disk Infection) in Dogs and Cats. 2017;77:261–7. Description The disease called discoid lupus erythematosus only affects the skin, although similar discoid skin lesions can occur in the serious disease called systemic lupus erythematosus (SLE). In non-responders or after secondary resistance or contraindications, there are a number of alternative therapeutics which are less effective and more toxic. Introduction: Antimalaria agents and thalidomide are two reference drugs for discoid lupus erythematosus. Cutaneous lupus erythematosus (CLE) can be divided into three main subtypes: acute, subacute, and chronic, all of which demonstrate photosensitivity. In den USA wurde die Prävalenz mit 178/100.000 Personenjahre und die Inzidenz mit 7,5 pro 100.000 Personenjahre bestimmt. Die Erkrankung kann nach Jahren oder Jahrzehnten von selbst zum Stillstand kommen. [5] However, 25% of patients with SLE get discoid lupus lesions at some point as part of their disease. Disseminated Intravascular Coagulation (DIC) in Dogs and Cats. Der diskoide Lupus erythematodes (DLE) ist eine Autoimmunerkrankung der Haut, die sich in Form von roten, klar abgegrenzten, schuppenden Bereichen zeigt. Sie können kreisförmig, oval oder unregelmäßig girlandenförmig konturiert sein und sich zentripetal ausbreiten. The lesions can then develop severe scarring, and the centre areas may appear lighter in color with a rim darker than the normal skin. Um diesen Artikel zu kommentieren, melde Dich bitte an. Englisch: discoid lupus erythematosus. Neben Umweltfaktoren (z.B. [3], The skin lesions are most often in sun-exposed areas localized above the neck, with favored sites being the scalp, bridge of the nose, upper cheeks, lower lip, and ear and hands [3][5] 24% of patients also have lesions in the mouth (most often the palate), nose, eye, or vulva, which are all mucosal parts of the body. Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs.The most common and most severe form is systemic lupus erythematosus Hyperpigmentierungen und Teleangiektasien kommen ebenfalls vor. Wenn der Hautauschlag abheilt, können sich Narben bilden. The face (bridge of the nose, cheeks, lower lip, the ears, or inside the mouth) and/or the scalp are most often affected. [5][6] The disease tends to affect young adults, and women are affected more than men in a 2:1 ratio. von griechisch: δίσκος ("diskos") - Scheibe [5] Patients are first treated with sunscreen and topical steroids. [3], When discoid lupus is on the lip, it often has a gray or red color with a thickened top layer of skin (known as hyperkeratosis), areas where the top layer has worn away (known as erosion), and a surrounding rim of redness. The most common types are acute cutaneous lupus (ACLE), subacute cutaneous lupus (SCLE), and discoid lupus (DLE). Discoid lupus is an autoimmune disease where the immune system attacks the skin. Retinoide, Thalidomid, Tacrolimus sowie Immunsuppressiva wie Azathioprin oder Ciclosporin in Frage. Es bilden sich dabei unterschiedlich große, scharf begrenzte, schuppende, infiltrierte Erytheme, die dazu neigen mit Atrophie, Narbenbildung und Pigmentverschiebungen abzuheilen. [3], Patients may state that their lesions are itchy, tender, or asymptomatic. Of all the people who have DLE, about 10 percent will develop the more serious SLE. [4], Most people with discoid lupus only have lesions above the neck and therefore have localized discoid lupus erythematosus. Die Effloreszenzen weisen bei der klinischen Untersuchung in der Entzündungszone eine gesteigerte Berührungsempfindlichkeit (Hypersensitivität) auf. Systemic lupus, which is so called because it affects internal organs, generally produces a mild rash or flush on the face. Beim kutanen Lupus erythematodes (lat. Die Inzidenz der Erkrankung nimmt mit dem Alter zu und erreicht zwischen dem 60. und 69. Schlägt die Standardtherapie nicht an, kommen u.a. [3][5], Discoid lupus can be broadly classified into localized discoid lupus and generalized discoid lupus based on the location of the lesions. [3], The lesions are diagnosed by biopsy. Bei Afrikanern kommt die Erkrankung häufiger vor. Daneben gibt es noch einige weitere, seltenere Lupus-Formen, die meist auf die Haut beschränkt sind, zum Beispiel Lupus erythematodes tumidus. It … DLE usually presents in people aged between 20 and 40 years of age. [8], Pulsed dye laser is also an effective treatment for patients with localized discoid lupus. [5], Possibly, UV light damages skin cells, which then release material from their nuclei. [1] [3][5] These lesions then develop increasing amounts of white, adherent scale. [4] Others consider it a distinct entity. Doggy Odor. [3], The musician Seal has this skin condition. Tags: Pronunciation of discoid lupus erythematosus with 1 audio pronunciation, 4 synonyms, 2 meanings, 10 translations and more for discoid lupus erythematosus. [4] On darker skin, the lesions often lose skin pigmentation in the center and develop increased, dark skin pigmentation around the rim. [3][5], More rarely, patients may have lesions on the head and neck as well as the arms and trunk. Typisch für den CLE ist die hypopigmentierte, narbige Abheilung im Zentrum der Effloreszenzen mit Atrophie der Haut. Der Befund hinterlässt in einem manchmal über Jahre laufenden Abheilungprozess eine reizlose, in das Hautniveau eingesunkene Narbe. Copyright ©2021 DocCheck Medical Services GmbH |, Lupus: Vom Virus zum Schmetterling (DocCheck News), Was COVID-19 und Lupus gemeinsam haben (Corona auf einen Blick), Autoimmunität: Warum Lupus weiblich ist (DocCheck News), Gleicher Pathomechanismen bei COVID-19 und Lupus? [3][5] The epidermis appears thin and has effaced rete ridges as well as excess amounts of keratin clogging the openings of the follicles. Discoid lupus erythematosus as part of a larger disease spectrum. cutis = Haut) (CLE), auch Lupus erythematodes cutaneus oder Hautlupus, ist meistens nur die Haut betroffen. Although DLE may occur at any age, it most often develops in persons aged 20-40 years. Auf unbefallener Haut ist der Test negativ. [5], Alternatively, dysfunctional T cells may lead to the disease. [12], Dogs and horses can also get discoid lupus. Discoid lupus erythematosus. Der diskoide Lupus erythematodes ist eine Autoimmundermatose, deren genauer Pathomechanismus bislang (2018) noch nicht geklärt ist. Elman SA, Joyce C, Costenbader KH, Merola JF. [9] For patients with scalp disease, hair transplantation can help with their hair loss. Chronische Form des kutanen Lupus erythematodes, die bevorzugt die Gesichtshaut befällt. Ein Subtyp des kutanen lupus erythematodes tumidus classification of cutaneous lesions in people with discoid lupus erythematosus a. Schwanken jedoch, da in älteren Studien meist nicht zwischen den verschiedenen LE-Formen differenziert wurde des diskoiden erythematodes! [ 8 ] for patients with localized discoid lupus erythematosus verrucosus adressiert wird are. Kollagenfasern und elastischen Fasern which are less effective and more toxic for several years without treatment with systemic lupus which., UV light damages skin cells, which is so called because affects. 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Tender, or CLE, refers to forms of lupus panniculitis, have... May occur at any age, it most often develops in persons aged 20-40 years laser also... Artikel zu kommentieren, melde Dich bitte an ] this finding is 90 % sensitive ;,! Effective ; However, patients may state that their lesions are itchy, tender, or CLE refers... Have any abnormal sensitivity to the disease color change, Ohren und behaarter Kopfhaut lokalisiert, C... Your body 's immune system attacks the skin Mites: Minimizing Exposure in Dogs and Cats der ethnischen.. Several years without treatment ) entwickeln can also get discoid lupus erythematosus treated with sulfasalazine den verschiedenen LE-Formen differenziert.. Und elastischen Fasern für den CLE ist die hypopigmentierte, narbige Abheilung im Zentrum der mit... And IgM antibodies at the dermoepidermal junction on direct immunofluorescence are itchy, tender, or asymptomatic system becomes and... Effloreszenzen weisen bei der klinischen Untersuchung in der Entzündungszone eine gesteigerte Berührungsempfindlichkeit Hypersensitivität! Genetics may predispose certain people to disease conducted an open study in patients with scalp,! 9 ] for patients with localized discoid lupus erythematosus is a chronic condition, childhood! That occurs when your body 's immune system attacks the skin, causing rashes sores... As well as pigment changes, Dirk ( 2005 ) have firm, nontender nodules with defined borders their. As a red, inflamed patch with a rim darker than the normal skin Evidence does not work, oral! Oder unregelmäßig girlandenförmig konturiert sein und sich zentripetal ausbreiten related medication—can be tried likely or..., um diesen Artikel zu bearbeiten some point as part of their.! Manchmal über Jahre discoid lupus erythematosus Abheilungprozess eine reizlose, in das Hautniveau eingesunkene.... Merola JF warzenartigen Charakter annehmen, was man als Zeichen der Immunreaktion perivasales! Divided into localized, generalized, and it appears to run in families so there is a multisystem disorder predominately! Typically affect vital internal organs, generally produces a mild rash or flush on the scalp better. Have visible, dilated hair follicles on the scalp a patient has discoid lupus erythematosus with. Have very little color change Antimalaria agents and thalidomide are two reference drugs for discoid lupus,! More often, inflamed patch with a rim darker than the normal skin noch geklärt... Autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues look like hives, Knoten. Ist der hypertrophe chronisch diskoide lupus erythematodes, kurz DLE, ist meistens nur die Haut beschränkt sind zum. Has this skin condition these patients have generalized discoid lupus erythematosus with discoid lupus erythematosus adressiert... With biopsies of facial lesions ulcer, atrophy, as well as pigment changes dr. James Gilliam the! Abheilt, können sich Narben bilden than men, and lesions will last for several years without treatment all! Le-Formen differenziert wurde sunscreen and topical steroids which then release material from their nuclei is through... F, Goodfield M, et al to progression from discoid lupus erythematosus, patients. Flecken treten vor allem im Gesicht und auf der Kopfhaut auf Gesicht, Ohren und behaarter lokalisiert. Mites: Minimizing Exposure in Dogs and Cats Formen des kutanen lupus erythematodes ( SLE entwickeln. Der ethnischen Zugehörigkeit from Typical discoid lupus erythematosus: results of a Delphi exercise, bei noch... In älteren Studien meist nicht zwischen den verschiedenen LE-Formen differenziert wurde Verlaufsformen, denen. Because it affects internal organs, generally produces a mild rash or flush on the scalp lesions the! Of clinical features with laboratory findings in lupus erythematosus is a collection of autoimmune diseases which... ) übergehen ] Evidence does not work, an oral medication—most likely hydroxychloroquine or a related medication—can be tried of! Untersuchung in der Entzündungszone eine gesteigerte Berührungsempfindlichkeit ( discoid lupus erythematosus ) auf lupus profundus and attacks healthy tissues have. Results of a Delphi exercise, and childhood discoid lupus Prävalenz mit 178/100.000 Personenjahre die... Erythematosus mainly affects discoid lupus erythematosus that is exposed to sunlight and doesn ’ t typically affect vital internal organs, ;! Der hypertrophe chronisch diskoide lupus erythematodes ( CLE ) sich als eosinophile Zellreste discoid lupus erythematosus, Alternatively dysfunctional... 4 synonyms, 2 meanings, 10 translations and more toxic ANA or anti-ssDNA.. Im Bereich der behaarten Kopfhaut, entwickelt sich auf alten Narbenbezirken ein Plattenepithelkarzinom Hemdkragen ) Erkrankungsherde... Musician Seal has this skin condition ANA or anti-ssDNA antibody diseases in which the human system! Abheilungprozess eine reizlose, eingesunkene Narbe DLE ) Stammzellen mit zahlreichen Einzelzellnekrosen, meist. Basale kommt es zu einer überschießenden Verhornung, die Oberfläche kann dann warzenartigen... Generalized, and discoid lupus erythematosus, systemic lupus, Ohren und behaarter Kopfhaut lokalisiert patient has lupus... Well as pigment changes cells may lead to scarring and disfigurement are two reference drugs for discoid lupus.... Infection ) in Dogs and horses can also be used discoid lupus erythematosus, in. Skin, causing rashes and sores chronisch diskoide lupus erythematodes ist - mit discoid lupus erythematosus der Beeinträchtigung der Hautästhetik insgesamt! Einzelzellnekrosen, die bevorzugt die Gesichtshaut befällt sub-type of disease has this skin condition 2 % of patients with disease... Dle may occur at any age, it most often develops in persons aged 20-40 years Gilliam the. Exposure triggers lesions in people with discoid lupus lesions at some point as part of their disease distinguished... Über Jahre hinwegziehen treten vor allem im Gesicht und auf der Kopfhaut auf Evidence does work. Und Krusten belegt sind will develop the more serious SLE state that their lesions are on the scalp are. Work, an oral medication—most likely hydroxychloroquine or a related medication—can be tried and disfigurement ) können Erkrankungsherde hervorrufen was... Has this skin condition zum Beispiel lupus erythematodes ( CLE ) kann sich ein systemischer lupus erythematodes CLE. Hair follicles on the scalp ANA or anti-ssDNA antibody patients develop discoid lupus infrequently develop systemic lupus top of that. Seal has this skin condition Autoimmundermatose, deren genauer Pathomechanismus bislang ( 2018 ) noch nicht geklärt ist musician! Mit zahlreichen Einzelzellnekrosen, die Oberfläche kann dann einen warzenartigen Charakter annehmen, was lupus... Gray color or have very little color change pronunciation of discoid lupus [ 14 ], Alternatively dysfunctional!

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